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Cellosaurus M21L (CVCL_JZ12)

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Cell line name M21L
Synonyms M21-L; M21-Low
Accession CVCL_JZ12
Resource Identification Initiative To cite this cell line use: M21L (RRID:CVCL_JZ12)
Comments Characteristics: Lacks expression of integrin alpha-V (ITGAV).
Derived from site: Metastatic; Not specified.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (from parent cell line).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_D031 (M21)
Children:
CVCL_JZ14 (M21L22)CVCL_JZ13 (M21L4)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Web pages Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/m/cell-lines-detail-389.html
Publications

PubMed=2447074; DOI=10.1016/S0021-9258(18)45436-1
David A. Cheresh, Robert C. Spiro;
Biosynthetic and functional properties of an Arg-Gly-Asp-directed receptor involved in human melanoma cell attachment to vitronectin, fibrinogen, and von Willebrand factor.
J. Biol. Chem. 262:17703-17711(1987)

PubMed=1376331; DOI=10.1172/JCI115811; PMCID=PMC295910
Brunhilde Felding-Habermann, Barbara M. Mueller, Cynthia A. Romerdahl, David A. Cheresh;
Involvement of integrin alpha V gene expression in human melanoma tumorigenicity.
J. Clin. Invest. 89:2018-2022(1992)

Cross-references
Cell line databases/resources cancercelllines; CVCL_JZ12
Encyclopedic resources Wikidata; Q54903521
Entry history
Entry creation22-Aug-2017
Last entry update10-Apr-2025
Version number9