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Cellosaurus H357-VB6 (CVCL_JY68)

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Cell line name H357-VB6
Synonyms VB6
Accession CVCL_JY68
Resource Identification Initiative To cite this cell line use: H357-VB6 (RRID:CVCL_JY68)
Comments Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:6150; ITGAV.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:6161; ITGB6.
Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
Sequence variations
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly13Ser (c.37G>A); ClinVar=VCV000376323; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg110Cys (c.328C>T); ClinVar=VCV000142206; Zygosity=Homozygous (from parent cell line).
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_JY67 (H357-V3)
Sex of cell Male
Age at sampling 74Y
Category Cancer cell line
Publications

PubMed=11340566; DOI=10.1002/1097-0215(20010601)92:5<641::AID-IJC1243>3.0.CO;2-P
Gareth J. Thomas, Mark P. Lewis, Ian R. Hart, John F. Marshall, Paul M. Speight;
AlphaVbeta6 integrin promotes invasion of squamous carcinoma cells through up-regulation of matrix metalloproteinase-9.
Int. J. Cancer 92:641-650(2001)

PubMed=11442751; DOI=10.1046/j.0022-202x.2001.01379.x
Gareth J. Thomas, Mark P. Lewis, Simon A. Whawell, Alan Russell, Dean Sheppard, Ian R. Hart, Paul M. Speight, John F. Marshall;
Expression of the alphavbeta6 integrin promotes migration and invasion in squamous carcinoma cells.
J. Invest. Dermatol. 117:67-73(2001)

Cross-references
Encyclopedic resources Wikidata; Q54992947
Entry history
Entry creation22-Aug-2017
Last entry update19-Dec-2024
Version number12