Cellosaurus RT4-67 (CVCL_JK04)
Cell line name | RT4-67 |
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Synonyms | RT4-D6P2T clone 67 |
Accession | CVCL_JK04 |
Resource Identification Initiative | To cite this cell line use: RT4-67 (RRID:CVCL_JK04) |
Comments | Characteristics: Expression of NF2 is doxycycline-inducible as the parent cell line was transfected with reverse tetracycline-controlled transactivator (rtTA), a fusion between a mutated version of E.coli TetR and the activating domain of HSV-1 VP16 (PubMed=11316791). Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:7773; NF2. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (Note=With p.Met1_Arg360del). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Transformant: ChEBI; CHEBI_23995; N-ethyl-N-nitrosourea (ENU). Derived from site: In situ; Peripheral nervous system, sciatic nerve; UBERON=UBERON_0001322. Cell type: Schwann cell; CL=CL_0002573. |
Disease | Rat malignant schwannoma (NCIt: C60465) |
Species of origin | Rattus norvegicus (Rat)
(NCBI Taxonomy: 10116)
Breed/subspecies: BDIX; RS=RS_0000091. |
Hierarchy | Parent: CVCL_4006 (RT4-D6P2T) |
Category | Cancer cell line |
Publications | PubMed=11316791; DOI=10.1101/gad.189601; PMCID=PMC312675 PubMed=14580336; DOI=10.1016/S1097-2765(03)00382-4 PubMed=21481793; DOI=10.1016/j.ccr.2011.02.017; PMCID=PMC3075552 PubMed=28469964; PMCID=PMC5411799 |
Cross-references | |
Encyclopedic resources | Wikidata; Q54951361 |
Experimental variables resources | EFO; EFO_0022785 |
Entry history | |
Entry creation | 15-May-2017 |
Last entry update | 10-Apr-2025 |
Version number | 11 |