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Cellosaurus Don Q (CVCL_J503)

[Text version]
Cell line name Don Q
Synonyms CdtR-Q; CdtRQ
Accession CVCL_J503
Resource Identification Initiative To cite this cell line use: Don Q (RRID:CVCL_J503)
Comments Characteristics: Highly resistant to the two Rho-modifying glucosyltransferase toxins A and B of Clostridium difficile (PubMed=1816487; PubMed=8636120).
Transformant: ChEBI; CHEBI:23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; UniProtKB; O35156; Ugp2; Simple; p.Gly116Asp; Zygosity=Homozygous (PubMed=9295324).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_3472 (Don)
Children:
CVCL_D3W6 (Don QR)
Sex of cell Male
Age at sampling 8M
Category Spontaneously immortalized cell line
Publications

PubMed=1816487; DOI=10.1016/0882-4010(91)90019-7
Florin I.
Isolation of a fibroblast mutant resistant to Clostridium difficile toxins A and B.
Microb. Pathog. 11:337-346(1991)

PubMed=8636120; DOI=10.1074/jbc.271.12.6925
Chaves-Olarte E., Florin I., Boquet P., Popoff M., von Eichel-Streiber C., Thelestam M.
UDP-glucose deficiency in a mutant cell line protects against glucosyltransferase toxins from Clostridium difficile and Clostridium sordellii.
J. Biol. Chem. 271:6925-6932(1996)

PubMed=9295324; DOI=10.1074/jbc.272.38.23784
Flores-Diaz M., Alape-Giron A., Persson B., Pollesello P., Moos M., von Eichel-Streiber C., Thelestam M., Florin I.
Cellular UDP-glucose deficiency caused by a single point mutation in the UDP-glucose pyrophosphorylase gene.
J. Biol. Chem. 272:23784-23791(1997)

Cross-references
Encyclopedic resources Wikidata; Q54831354
Entry history
Entry creation11-Feb-2013
Last entry update30-Jan-2024
Version number9