ID   Don Q
AC   CVCL_J503
SY   CdtR-Q; CdtRQ
DR   Wikidata; Q54831354
RX   PubMed=1816487;
RX   PubMed=8636120;
RX   PubMed=9295324;
CC   Characteristics: Highly resistant to the two Rho-modifying glucosyltransferase toxins A and B of Clostridium difficile (PubMed=1816487; PubMed=8636120).
CC   Sequence variation: Mutation; UniProtKB; O35156; Ugp2; Simple; p.Gly116Asp; Zygosity=Homozygous (PubMed=9295324).
CC   Transformant: ChEBI; CHEBI:23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_3472 ! Don
SX   Male
AG   8M
CA   Spontaneously immortalized cell line
DT   Created: 11-02-13; Last updated: 30-01-24; Version: 9
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RX   PubMed=1816487; DOI=10.1016/0882-4010(91)90019-7;
RA   Florin I.;
RT   "Isolation of a fibroblast mutant resistant to Clostridium difficile
RT   toxins A and B.";
RL   Microb. Pathog. 11:337-346(1991).
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RX   PubMed=8636120; DOI=10.1074/jbc.271.12.6925;
RA   Chaves-Olarte E., Florin I., Boquet P., Popoff M.,
RA   von Eichel-Streiber C., Thelestam M.;
RT   "UDP-glucose deficiency in a mutant cell line protects against
RT   glucosyltransferase toxins from Clostridium difficile and Clostridium
RT   sordellii.";
RL   J. Biol. Chem. 271:6925-6932(1996).
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RX   PubMed=9295324; DOI=10.1074/jbc.272.38.23784;
RA   Flores-Diaz M., Alape-Giron A., Persson B., Pollesello P., Moos M.,
RA   von Eichel-Streiber C., Thelestam M., Florin I.;
RT   "Cellular UDP-glucose deficiency caused by a single point mutation in
RT   the UDP-glucose pyrophosphorylase gene.";
RL   J. Biol. Chem. 272:23784-23791(1997).
//