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Cellosaurus ISH/DDP (CVCL_IR24)

[Text version]

Cell line name ISH/DDP
Accession CVCL_IR24
Resource Identification Initiative To cite this cell line use: ISH/DDP (RRID:CVCL_IR24)
Comments Population: Japanese.
Doubling time: 40.1 hours (PubMed=22041447).
Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
Derived from sampling site: Endometrium.
Sequence variations
  • Mutation; HGNC; 8979; PIK3R1; Simple; p.Leu570Pro (c.1709T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9177; POLE; Simple; p.Pro102Ser (c.304C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9177; POLE; Simple; p.Asn751fs (c.2252delA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Thr319fs*1 (c.950_953delTACT) (p.VL317fs) (V317fs*3); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Glu288fs*3 (c.863delA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Asp49His (c.145G>C); ClinVar=VCV000135948; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Met246Val (c.736A>G); ClinVar=VCV000100815; Zygosity=Heterozygous (from parent cell line).
Disease Endometrial adenocarcinoma (NCIt: C7359)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2529 (Ishikawa)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line
Publications

PubMed=22041447; DOI=10.3760/cma.j.issn.0529-567x.2011.07.012
Xu Q.-Y., Chen Y.-H., Zhao L.-J., Li X.-P., Wang J.-L., Wei L.-H.
Establishment of cisplatin-resistant human endometrial cancer cell line and the study of its resistant mechanisms.
Zhonghua Fu Chan Ke Za Zhi 46:533-537(2011)

Cross-references
Encyclopedic resources Wikidata; Q54898277
Entry history
Entry creation03-Mar-2017
Last entry update16-Dec-2021
Version number6