ID   ISH/DDP
AC   CVCL_IR24
DR   cancercelllines; CVCL_IR24
DR   Wikidata; Q54898277
RX   PubMed=22041447;
CC   Population: Japanese.
CC   Doubling time: 40.1 hours (PubMed=22041447).
CC   Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
CC   Sequence variation: Mutation; HGNC; 8979; PIK3R1; Simple; p.Leu570Pro (c.1709T>C); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9177; POLE; Simple; p.Pro102Ser (c.304C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9177; POLE; Simple; p.Asn751fs (c.2252delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Thr319fs*1 (c.950_953delTACT) (p.VL317fs) (V317fs*3); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Glu288fs*3 (c.863delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Asp49His (c.145G>C); ClinVar=VCV000135948; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Met246Val (c.736A>G); ClinVar=VCV000100815; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
DI   NCIt; C7359; Endometrial adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2529 ! Ishikawa
SX   Female
AG   39Y
CA   Cancer cell line
DT   Created: 03-03-17; Last updated: 05-10-23; Version: 9
//
RX   PubMed=22041447; DOI=10.3760/cma.j.issn.0529-567x.2011.07.012;
RA   Xu Q.-Y., Chen Y.-H., Zhao L.-J., Li X.-P., Wang J.-L., Wei L.-H.;
RT   "Establishment of cisplatin-resistant human endometrial cancer cell
RT   line and the study of its resistant mechanisms.";
RL   Zhonghua Fu Chan Ke Za Zhi 46:533-537(2011).
//