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Cellosaurus MDA435/LCC6 (CVCL_IN99)

[Text version]
Cell line name MDA435/LCC6
Synonyms MDA-435/LCC6
Accession CVCL_IN99
Resource Identification Initiative To cite this cell line use: MDA435/LCC6 (RRID:CVCL_IN99)
Comments Problematic cell line: Contaminated. Parent cell line (MDA-MB-435) has been shown to be a M14 derivative.
Population: Caucasian.
Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0417 (MDA-MB-435)
Sex of cell Male
Age at sampling 33Y
Category Cancer cell line

PubMed=8546900; DOI=10.1038/bjc.1996.29
Leonessa F., Green D., Licht T., Wright A., Wingate-Legette K., Lippman J., Gottesman M.M., Clarke R.
MDA435/LCC6 and MDA435/LCC6MDR1: ascites models of human breast cancer.
Br. J. Cancer 73:154-161(1996)

Cell line databases/resources cancercelllines; CVCL_IN99
Anatomy/cell type resources BTO; BTO:0005866
Encyclopedic resources Wikidata; Q54904667
Entry history
Entry creation03-Mar-2017
Last entry update05-Oct-2023
Version number15