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Cellosaurus MDA435/LCC6MDR1 (CVCL_IP00)

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Cell line name MDA435/LCC6MDR1
Synonyms MDA435/LCC6MDR
Accession CVCL_IP00
Resource Identification Initiative To cite this cell line use: MDA435/LCC6MDR1 (RRID:CVCL_IP00)
Comments Problematic cell line: Contaminated. Grand-parent cell line (MDA-MB-435) has been shown to be a M14 derivative.
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:40; ABCB1.
Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_IN99 (MDA435/LCC6)
Sex of cell Male
Age at sampling 33Y
Category Cancer cell line
Publications

PubMed=8546900; DOI=10.1038/bjc.1996.29; PMCID=PMC2074305
Fabio Leonessa, Diane Green, Thomas Licht, Ann Wright, Kim Wingate-Legette, Jeremy Lippman, Michael Marc Gottesman, Robert Clarke;
MDA435/LCC6 and MDA435/LCC6MDR1: ascites models of human breast cancer.
Br. J. Cancer 73:154-161(1996)

Cross-references
Cell line databases/resources cancercelllines; CVCL_IP00
Anatomy/cell type resources BTO; BTO_0005867
Encyclopedic resources Wikidata; Q54904668
Entry history
Entry creation03-Mar-2017
Last entry update19-Dec-2024
Version number16