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Cellosaurus NCI-N87/TR (CVCL_IL03)

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Cell line name NCI-N87/TR
Accession CVCL_IL03
Resource Identification Initiative To cite this cell line use: NCI-N87/TR (RRID:CVCL_IL03)
Comments Selected for resistance to: DrugBank; DB00072; Trastuzumab (Herceptin).
Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Gene deletion; HGNC; HGNC:6770; SMAD4; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3431; ERBB3; Simple; p.Thr757Lys (c.2270C>A); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Gastric tubular adenocarcinoma (NCIt: C5473)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1603 (NCI-N87)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=26108989; DOI=10.1038/srep11634; PMCID=PMC4479993
Qiang Zuo, Jing Liu, Jing-Wen Zhang, Meng-Wan Wu, Li-Hong Guo, Wang-Jun Liao;
Development of trastuzumab-resistant human gastric carcinoma cell lines and mechanisms of drug resistance.
Sci. Rep. 5:11634.1-11634.11(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_IL03
Encyclopedic resources Wikidata; Q54908218
Entry history
Entry creation01-Dec-2016
Last entry update19-Dec-2024
Version number14