ID   NCI-N87/TR
AC   CVCL_IL03
DR   cancercelllines; CVCL_IL03
DR   Wikidata; Q54908218
RX   PubMed=26108989;
CC   Selected for resistance to: DrugBank; DB00072; Trastuzumab (Herceptin).
CC   Sequence variation: Gene deletion; HGNC; 6770; SMAD4; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3431; ERBB3; Simple; p.Thr757Lys (c.2270C>A); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
DI   NCIt; C5473; Gastric tubular adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1603 ! NCI-N87
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 05-10-23; Version: 13
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RX   PubMed=26108989; DOI=10.1038/srep11634;
RA   Zuo Q., Liu J., Zhang J.-W., Wu M.-W., Guo L.-H., Liao W.-J.;
RT   "Development of trastuzumab-resistant human gastric carcinoma cell
RT   lines and mechanisms of drug resistance.";
RL   Sci. Rep. 5:11634-11634(2015).
//