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Cellosaurus HUH7-ins (CVCL_HA62)

[Text version]
Cell line name HUH7-ins
Synonyms Huh7ins
Accession CVCL_HA62
Resource Identification Initiative To cite this cell line use: HUH7-ins (RRID:CVCL_HA62)
Comments Population: Japanese.
Characteristics: Secretes insulin in a regulated manner in response to glucose, calcium and theophylline.
Transfected with: HGNC; 6081; INS.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0336 (Huh-7)
CVCL_HA63 (Melligen)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line

PubMed=12621453; DOI=10.1038/sj.gt.3301911
Tuch B.E., Szymanska B., Yao M., Tabiin M.T., Gross D.J., Holman S., Swan M.A., Humphrey R.K.B., Marshall G.M., Simpson A.M.
Function of a genetically modified human liver cell line that stores, processes and secretes insulin.
Gene Ther. 10:490-503(2003)

PubMed=21084851; DOI=10.4161/isl.1.1.8994
Lutherborrow M.A., Appavoo M., Simpson A.M., Tuch B.E.
Gene expression profiling of HUH7-ins: lack of a granulogenic function for chromogranin A.
Islets 1:62-74(2009)

Simpson A.M., Tao C.
Cells genetically modified to comprise pancreatic islet glucokinase and uses thereof.
Patent number US10738285, 11-Aug-2020

Cell line databases/resources cancercelllines; CVCL_HA62
Encyclopedic resources Wikidata; Q54896861
Entry history
Entry creation26-Sep-2016
Last entry update05-Oct-2023
Version number16