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Cellosaurus HEP G2ins (CVCL_HA60)

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Cell line name HEP G2ins
Synonyms HEPG2ins; HepG2ins
Accession CVCL_HA60
Resource Identification Initiative To cite this cell line use: HEP G2ins (RRID:CVCL_HA60)
Comments Group: Patented cell line.
Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:6081; INS.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Children:
CVCL_HA61 (HEP G2ins/g)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

Patent=WO1995032740A1
Bernard Edward Tuch, Ann Margaret Simpson, Glenn Mark Marshall;
Transformed human hepatoma cell line which releases insulin.
Patent number WO1995032740A1, 07-Dec-1995

PubMed=7614254
Ann Margaret Simpson, Bernard Edward Tuch, M. Anne Swan, Jian Tu, Glenn Mark Marshall;
Functional expression of the human insulin gene in a human hepatoma cell line (HEP G2).
Gene Ther. 2:223-231(1995)

PubMed=12958175; DOI=10.1096/fj.02-0051fje; PMCID=PMC2132862
Guo-Jun Liu, Ann Margaret Simpson, M. Anne Swan, Chang Tao, Bernard Edward Tuch, Russell M. Crawford, Aleksandar Jovanovic, Donald K. Martin;
ATP-sensitive potassium channels induced in liver cells after transfection with insulin cDNA and the GLUT 2 transporter regulate glucose-stimulated insulin secretion.
FASEB J. 17:1682-1684(2003)

Cross-references
Cell line databases/resources cancercelllines; CVCL_HA60
Encyclopedic resources Wikidata; Q54882748
Entry history
Entry creation26-Sep-2016
Last entry update14-Aug-2025
Version number17