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Cellosaurus MIP-101 (CVCL_H689)

[Text version]
Cell line name MIP-101
Synonyms MIP 101; MIP101
Accession CVCL_H689
Resource Identification Initiative To cite this cell line use: MIP-101 (RRID:CVCL_H689)
Comments Group: Space-flown cell line (cellonaut).
Doubling time: 22 hours (PubMed=3442732); 15.7 hours (PubMed=7757961).
Microsatellite instability: Instable (MSI) (PubMed=23671654; PubMed=25926053).
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Anecdotal: Have been flown in space on shuttle flights STS-70 and STS-85 to study growth in microgravity (PubMed=10949995).
Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations
HLA typing Source: PubMed=25960936
Class I
HLA-AA*24:02,02:01
HLA-BB*35:08,35:08
HLA-CC*07:01,04:01
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C9CQ (MIP-CEA clone 17)CVCL_C9CR (MIP-CEA clone 6)CVCL_C9CS (MIP-CEA clone 8)
CVCL_C9CT (MIP-neo)CVCL_HE61 (MIP/5FU)CVCL_HE62 (MIP/CIS)
CVCL_HE63 (MIP/CPT)CVCL_HE64 (MIP/ETO)
Sex of cell Male
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): PubMed=25926053

Markers:
AmelogeninX
CSF1PO12
D5S81813
D7S82010,11.3
D13S3178,11
D16S53912,13
D21S1129,32.2
TH017,9.3
TPOX8,11
vWA18,19

Run an STR similarity search on this cell line
Publications

PubMed=3442732; DOI=10.3109/07357908709020314
Richard M. Niles, Sally A. Wilhelm, Glenn D. Steele Jr., Bohdana Burke, Thomas Christensen, Daniel L. Dexter, Michael J. O'Brien, Peter Thomas, Norman Zamcheck;
Isolation and characterization of an undifferentiated human colon carcinoma cell line (MIP-101).
Cancer Invest. 5:545-552(1987)

PubMed=2228514
Hans E. Wagner, Peter Thomas, Barbara C. Wolf, Norman Zamcheck, John Milburn Jessup, Glenn D. Steele Jr.;
Characterization of the tumorigenic and metastatic potential of a poorly differentiated human colon cancer cell line.
Invasion Metastasis 10:253-266(1990)

PubMed=7651727
William Vasilios Kastrinakis, Nirasha Ramchurren, Karen M. Rieger, Donald T. Hess, Massimo Loda, Glenn Steele, Ian C. Summerhayes;
Increased incidence of p53 mutations is associated with hepatic metastasis in colorectal neoplastic progression.
Oncogene 11:647-652(1995)

PubMed=7757961; DOI=10.1016/0304-3835(95)03764-n
Peter Thomas, Aniruddha Gangopadhyay, Glenn D. Steele Jr., Charles Andrews, Hiroshi Nakazato, Shinzo Oikawa, John Milburn Jessup;
The effect of transfection of the CEA gene on the metastatic behavior of the human colorectal cancer cell line MIP-101.
Cancer Lett. 92:59-66(1995)

PubMed=10949995; DOI=10.1290/1071-2690(2000)036<0367:MCRAAI>2.0.CO;2
John Milburn Jessup, Marylin Frantz, Enigul Sonmez-Alpan, Joseph D. Locker, Kimberly Skena, Heather Waller, Paul Battle, Alex Nachman, Mary Ellen Weber, Donald A. Thomas, Robert Lee Curbeam Jr. ...Show all 13 authors... , Tacey L. Baker, Thomas J. Goodwin; Show fewer authors
Microgravity culture reduces apoptosis and increases the differentiation of a human colorectal carcinoma cell line.
In Vitro Cell. Dev. Biol. Anim. 36:367-373(2000)

PubMed=15902309; DOI=10.1172/JCI23002; PMCID=PMC1090471
Isabella T. Tai, Meiru Dai, David A. Owen, Lan-Bo Chen;
Genome-wide expression analysis of therapy-resistant tumors reveals SPARC as a novel target for cancer therapy.
J. Clin. Invest. 115:1492-1502(2005)

PubMed=20835245; DOI=10.1038/nmeth.1503
Malachi Griffith, Obi L. Griffith, Jill Mwenifumbo, Rodrigo Goya, Anca Sorana Morrissy, Ryan D. Morin, Richard D. Corbett, Michelle J. Tang, Ying-Chen Hou, Trevor J. Pugh, Gordon Robertson ...Show all 26 authors... , Suganthi Chittaranjan, Adrian Ally, Jennifer K. Asano, Susanna Y. Chan, Hai-Yan I. Li, Helen McDonald, Kevin Teague, Yong-Jun Zhao, Thomas Zeng, Allen Delaney, Martin Hirst, Gregg B. Morin, Steven J.M. Jones, Isabella T. Tai, Marco Antonio Marra; Show fewer authors
Alternative expression analysis by RNA sequencing.
Nat. Methods 7:843-847(2010)

PubMed=23671654; DOI=10.1371/journal.pone.0063056; PMCID=PMC3646030
Yu-Heng Lu, T. David Soong, Olivier Elemento;
A novel approach for characterizing microsatellite instability in cancer cells.
PLoS ONE 8:e63056.1-e63056.10(2013)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Sebastian Boegel, Martin Lower, Thomas Bukur, Ugur Sahin, John C. Castle;
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25926053; DOI=10.1038/ncomms8002
Enzo Medico, Mariangela Russo, Gabriele Picco, Carlotta Cancelliere, Emanuele Valtorta, Giorgio Corti, Michela Buscarino, Claudio Isella, Simona Lamba, Barbara Martinoglio, Silvio Veronese ...Show all 19 authors... , Salvatore Siena, Andrea Sartore-Bianchi, Marco Beccuti, Marcella Mottolese, Michael Linnebacher, Francesca Cordero, Federica Di Nicolantonio, Alberto Bardelli; Show fewer authors
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_H689
ColonAtlas; MIP101
Encyclopedic resources Wikidata; Q54905751
Gene expression databases GEO; GSM587038
GEO; GSM1448116
Polymorphism and mutation databases Cosmic; 1374639
IARC_TP53; 4562
Entry history
Entry creation11-Feb-2013
Last entry update10-Apr-2025
Version number18