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Cellosaurus MIP-101 (CVCL_H689)

[Text version]
Cell line name MIP-101
Synonyms MIP 101; MIP101
Accession CVCL_H689
Resource Identification Initiative To cite this cell line use: MIP-101 (RRID:CVCL_H689)
Comments Group: Space-flown cell line (cellonaut).
Doubling time: 22 hours (PubMed=3442732).
Microsatellite instability: Instable (MSI) (PubMed=23671654; PubMed=25926053).
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Anecdotal: Have been flown in space on shuttle flights STS-70 and STS-85 to study growth in microgravity (PubMed=10949995).
Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser241Phe (c.722C>T); ClinVar=VCV000012359; Zygosity=Unspecified (PubMed=7651727).
HLA typing Source: PubMed=25960936
Class I
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
Sex of cell Male
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): PubMed=25926053


Run an STR similarity search on this cell line

PubMed=3442732; DOI=10.3109/07357908709020314
Niles R.M., Wilhelm S.A., Steele G.D. Jr., Burke B., Christensen T., Dexter D.L., O'Brien M.J., Thomas P., Zamcheck N.
Isolation and characterization of an undifferentiated human colon carcinoma cell line (MIP-101).
Cancer Invest. 5:545-552(1987)

Wagner H.E., Thomas P., Wolf B.C., Zamcheck N., Jessup J.M., Steele G.D. Jr.
Characterization of the tumorigenic and metastatic potential of a poorly differentiated human colon cancer cell line.
Invasion Metastasis 10:253-266(1990)

Kastrinakis W.V., Ramchurren N., Rieger K.M., Hess D.T., Loda M., Steele G., Summerhayes I.C.
Increased incidence of p53 mutations is associated with hepatic metastasis in colorectal neoplastic progression.
Oncogene 11:647-652(1995)

PubMed=10949995; DOI=10.1290/1071-2690(2000)036<0367:MCRAAI>2.0.CO;2
Jessup J.M., Frantz M., Sonmez-Alpan E., Locker J.D., Skena K., Waller H., Battle P., Nachman A., Weber M.E., Thomas D.A., Curbeam R.L. Jr., Baker T.L., Goodwin T.J.
Microgravity culture reduces apoptosis and increases the differentiation of a human colorectal carcinoma cell line.
In Vitro Cell. Dev. Biol. Anim. 36:367-373(2000)

PubMed=15902309; DOI=10.1172/JCI23002
Tai I.T., Dai M., Owen D.A., Chen L.B.
Genome-wide expression analysis of therapy-resistant tumors reveals SPARC as a novel target for cancer therapy.
J. Clin. Invest. 115:1492-1502(2005)

PubMed=20835245; DOI=10.1038/nmeth.1503
Griffith M., Griffith O.L., Mwenifumbo J., Goya R., Morrissy A.S., Morin R.D., Corbett R., Tang M.J., Hou Y.-C., Pugh T.J., Robertson G., Chittaranjan S., Ally A., Asano J.K., Chan S.Y., Li H.-Y.I., McDonald H., Teague K., Zhao Y.-J., Zeng T., Delaney A., Hirst M., Morin G.B., Jones S.J.M., Tai I.T., Marra M.A.
Alternative expression analysis by RNA sequencing.
Nat. Methods 7:843-847(2010)

PubMed=23671654; DOI=10.1371/journal.pone.0063056
Lu Y.-H., Soong T.D., Elemento O.
A novel approach for characterizing microsatellite instability in cancer cells.
PLoS ONE 8:E63056-E63056(2013)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

Cell line databases/resources ColonAtlas; MIP101
Encyclopedic resources Wikidata; Q54905751
Gene expression databases GEO; GSM587038
GEO; GSM1448116
Polymorphism and mutation databases Cosmic; 1374639
IARC_TP53; 4562
Entry history
Entry creation11-Feb-2013
Last entry update29-Jun-2023
Version number15