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Cellosaurus 4T1.2 (CVCL_GR32)

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Cell line name 4T1.2
Synonyms 4 T1.2
Accession CVCL_GR32
Resource Identification Initiative To cite this cell line use: 4T1.2 (RRID:CVCL_GR32)
Comments Characteristics: High propensity to metastasize spontaneously to bone, causing fractures and/or hindlimb paralysis (ATCC=CRL-3406).
Selected for resistance to: ChEBI; CHEBI_9555; Tioguanine (6-thioguanine; 6-TG).
Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
Disease Malignant neoplasms of the mouse mammary gland (NCIt: C21678)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: BALB/cfC3H.
Hierarchy Parent: CVCL_0125 (4T1)
Children:
CVCL_E8TB (4T1.2 luc1)CVCL_E8TC (4T1.2 luc2)CVCL_E8TD (4T1.2 luc3)
CVCL_E8TE (4T1.2 luc4)CVCL_E8TF (4T1.2 luc5)CVCL_E3GI (HyCyte 4T1.2-Luc)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=10411109; DOI=10.1023/A:1006689719505
Maria Lelekakis, Jane M. Moseley, Thomas John Martin, Daphne Hards, Elizabeth Deborah Williams, Patricia W.M. Ho, Darren Lowen, Jeannie Javni, Fred R. Miller, John Slavin, Robin L. Anderson;
A novel orthotopic model of breast cancer metastasis to bone.
Clin. Exp. Metastasis 17:163-170(1999)

PubMed=15671244; DOI=10.1158/1541-7786.1.3.1
Bedrich L. Eckhardt, Belinda S. Parker, Ryan K. van Laar, Christina M. Restall, Anthony L. Natoli, Michael D. Tavaria, Kym L. Stanley, Erica K. Sloan, Jane M. Moseley, Robin L. Anderson;
Genomic analysis of a spontaneous model of breast cancer metastasis to bone reveals a role for the extracellular matrix.
Mol. Cancer Res. 3:1-13(2005)

PubMed=22510147; DOI=10.1186/1480-9222-14-6; PMCID=PMC3473320
Celeste Bolin, Caleb Daniel Sutherland, Ken Tawara, Jim Moselhy, Cheryl Lynn Jorcyk;
Novel mouse mammary cell lines for in vivo bioluminescence imaging (BLI) of bone metastasis.
Biol. Proced. Online 14:6.1-6.10(2012)

Cross-references
Cell line collections (Providers) ATCC; CRL-3406
Chemistry resources ChEMBL-Cells; CHEMBL4483001
ChEMBL-Targets; CHEMBL4483221
PubChem_Cell_line; CVCL_GR32
Encyclopedic resources Wikidata; Q54603658
Entry history
Entry creation26-Sep-2016
Last entry update14-Aug-2025
Version number9