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Cellosaurus MCF-10A PTEN(+/-) (CVCL_F6LX)

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Cell line name MCF-10A PTEN(+/-)
Synonyms PTEN+/−
Accession CVCL_F6LX
Resource Identification Initiative To cite this cell line use: MCF-10A PTEN(+/-) (RRID:CVCL_F6LX)
Comments Characteristics: Heterozygous PTEN knockout generated by targeted deletion of exon 2 (PubMed=19843859).
Knockout cell: Method=Homologous recombination; HGNC; HGNC:9588; PTEN (Note=1 of 2 alleles).
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0598 (MCF-10A)
Children:
CVCL_F6LY (MCF-10A PTEN(-/-))
Sex of cell Female
Age at sampling 36Y
Category Spontaneously immortalized cell line
Publications

PubMed=19843859; DOI=10.1158/0008-5472.CAN-09-1067; PMCID=PMC2783190
Michele I. Vitolo, Michele B. Weiss, Marta Szmacinski, Khola Tahir, Todd Waldman, Ben Ho Park, Stuart S. Martin, David J. Weber, Kurtis E. Bachman;
Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cells.
Cancer Res. 69:8275-8283(2009)

Entry history
Entry creation22-Oct-2026
Last entry update22-Oct-2026
Version number1