ID   MCF-10A PTEN(+/-)
AC   CVCL_F6LX
SY   PTEN+/−
RX   PubMed=19843859;
CC   Characteristics: Heterozygous PTEN knockout generated by targeted deletion of exon 2 (PubMed=19843859).
CC   Knockout cell: Method=Homologous recombination; HGNC; HGNC:9588; PTEN (Note=1 of 2 alleles).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0598 ! MCF-10A
SX   Female
AG   36Y
CA   Spontaneously immortalized cell line
DT   Created: 22-10-26; Last updated: 22-10-26; Version: 1
CH   CVCL_F6LY ! MCF-10A PTEN(-/-)
//
RX   PubMed=19843859; DOI=10.1158/0008-5472.CAN-09-1067; PMCID=PMC2783190;
RA   Vitolo, Michele I.
RA   Weiss, Michele B.
RA   Szmacinski, Marta
RA   Tahir, Khola
RA   Waldman, Todd
RA   Park, Ben Ho
RA   Martin, Stuart S.
RA   Weber, David J.
RA   Bachman, Kurtis E.
RT   "Deletion of PTEN promotes tumorigenic signaling, resistance to
RT   anoikis, and altered response to chemotherapeutic agents in human
RT   mammary epithelial cells.";
RL   Cancer Res. 69:8275-8283(2009).
//