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Cellosaurus MB135 (CVCL_F1IZ)

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Cell line name MB135
Accession CVCL_F1IZ
Resource Identification Initiative To cite this cell line use: MB135 (RRID:CVCL_F1IZ)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=MGI; MGI:88357; Cdk4.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Thigh, quadriceps skeletal muscle; UBERON=UBERON_0004498.
Cell type: Myoblast; CL=CL_0000056.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_F1JH (MB135-iDUX4)
Sex of cell Female
Age at sampling Age unspecified
Category Telomerase immortalized cell line
Publications

PubMed=28171552; DOI=10.1093/hmg/ddw271; PMCID=PMC6078597
Sujatha Jagannathan, Sean C. Shadle, Rebecca Resnick, Lauren D. Snider, Rabi Nabil Tawil, Silvere Maria van der Maarel, Robert K. Bradley, Stephen Justice Tapscott;
Model systems of DUX4 expression recapitulate the transcriptional profile of FSHD cells.
Hum. Mol. Genet. 25:4419-4431(2016)

PubMed=29533181; DOI=10.7554/eLife.31023; PMCID=PMC5849414
Amy E. Campbell, Sean C. Shadle, Sujatha Jagannathan, Jong-Won Lim, Rebecca Resnick, Rabi Nabil Tawil, Silvere Maria van der Maarel, Stephen Justice Tapscott;
NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins.
eLife 7:e31023.1-e31023.27(2018)

Entry history
Entry creation27-Nov-2025
Last entry update27-Nov-2025
Version number1