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Cellosaurus LR.4 (CVCL_F0B5)

[Text version]
Cell line name LR.4
Accession CVCL_F0B5
Resource Identification Initiative To cite this cell line use: LR.4 (RRID:CVCL_F0B5)
Comments Characteristics: MHC H-2 deficient due to loss of transcription of B2m and class I H-2 genes (PubMed=1627535).
Selected for resistance to: ChEBI; CHEBI_472552; 5-bromo-2'-deoxyuridine (Bromodeoxyuridine; BrdU; BUdR).
Transformant: ChEBI; CHEBI_34342; 3-methylcholanthrene (3-MC; 20-methylcholanthrene; 20-MC; MCA).
Derived from site: In situ; Thymus; UBERON=UBERON_0002370.
Cell type: T-cell; CL=CL_0000084.
Disease Mouse thymic lymphoma (NCIt: C134997)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: DBA/2.
Hierarchy Parent: CVCL_2097 (L-5178-Y)
Sex of cell Female
Age at sampling 8M
Category Cancer cell line
Publications

PubMed=1627535; DOI=10.1111/j.1744-313x.1992.tb00053.x
G. Nava, Rodolfo Benjamin Ocadiz-Delgado, Venancio Ortega, Guillermo Alfaro;
Damage in B2m genes and DNA methylation of H-2 genes are involved in loss of expression of class I MHC products on the membrane of LR.4, a cell line derivative of the T-cell lymphoma L5178Y.
Eur. J. Immunogenet. 19:141-158(1992)

PubMed=9104580; DOI=10.1046/j.1365-2370.1997.00250.x
Emma Verastegui, Roxana del Rio, Venancio Ortega, Guillermo Alfaro;
Specific recognition and rejection of the H-2-deficient cell line LR.4 by C57BL/6J mice.
Eur. J. Immunogenet. 24:93-103(1997)

Entry history
Entry creation14-Aug-2025
Last entry update14-Aug-2025
Version number1