ID   LR.4
AC   CVCL_F0B5
RX   PubMed=1627535;
RX   PubMed=9104580;
CC   Characteristics: MHC H-2 deficient due to loss of transcription of B2m and class I H-2 genes (PubMed=1627535).
CC   Selected for resistance to: ChEBI; CHEBI_472552; 5-bromo-2'-deoxyuridine (Bromodeoxyuridine; BrdU; BUdR).
CC   Transformant: ChEBI; CHEBI_34342; 3-methylcholanthrene (3-MC; 20-methylcholanthrene; 20-MC; MCA).
CC   Derived from site: In situ; Thymus; UBERON=UBERON_0002370.
CC   Cell type: T-cell; CL=CL_0000084.
CC   Breed/subspecies: DBA/2.
DI   NCIt; C134997; Mouse thymic lymphoma
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_2097 ! L-5178-Y
SX   Female
AG   8M
CA   Cancer cell line
DT   Created: 14-08-25; Last updated: 14-08-25; Version: 1
//
RX   PubMed=1627535; DOI=10.1111/j.1744-313x.1992.tb00053.x;
RA   Nava, G.
RA   Ocadiz-Delgado, Rodolfo Benjamin
RA   Ortega, Venancio
RA   Alfaro, Guillermo
RT   "Damage in B2m genes and DNA methylation of H-2 genes are involved in
RT   loss of expression of class I MHC products on the membrane of LR.4, a
RT   cell line derivative of the T-cell lymphoma L5178Y.";
RL   Eur. J. Immunogenet. 19:141-158(1992).
//
RX   PubMed=9104580; DOI=10.1046/j.1365-2370.1997.00250.x;
RA   Verastegui, Emma
RA   del Rio, Roxana
RA   Ortega, Venancio
RA   Alfaro, Guillermo
RT   "Specific recognition and rejection of the H-2-deficient cell line
RT   LR.4 by C57BL/6J mice.";
RL   Eur. J. Immunogenet. 24:93-103(1997).
//