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Cellosaurus huSP (CVCL_F0A3)

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Cell line name huSP
Accession CVCL_F0A3
Resource Identification Initiative To cite this cell line use: huSP (RRID:CVCL_F0A3)
Comments Population: Japanese.
Virology: Contains multiple copies of integrated hepatitis B virus (HBV) genomes. Compared to parent cell line, has a higher production of hepatitis B surface antigen. Produces no HBV core or E antigens (PubMed=2982143).
Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:903; AXIN1; Simple; p.Asn302Profs*111 (c.904_907delAACC); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg110Leu (c.329G>T); ClinVar=VCV000406597; Zygosity=Homozygous (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2956 (HuH-1)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=2982143; DOI=10.1073/pnas.82.1.208; PMCID=PMC397001
Hiroshi Mizusawa, Masanori Taira, Katsuyuki Yaginuma, Midori Kobayashi, Eisaku Yoshida, Katsuro Koike;
Inversely repeating integrated hepatitis B virus DNA and cellular flanking sequences in the human hepatoma-derived cell line huSP.
Proc. Natl. Acad. Sci. U.S.A. 82:208-212(1985)

Entry history
Entry creation14-Aug-2025
Last entry update14-Aug-2025
Version number1