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Cellosaurus DR-EcoScreen (CVCL_EG66)

[Text version]
Cell line name DR-EcoScreen
Accession CVCL_EG66
Resource Identification Initiative To cite this cell line use: DR-EcoScreen (RRID:CVCL_EG66)
Comments Biotechnology: Used in a bioassay for the determination of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (DL-PCBs) in environmental and food samples.
Characteristics: Acts through the activation of a luciferase reporter gene under the control of dioxin-response elements (DREs).
Transfected with: UniProtKB; P08659; Firefly luciferase.
Transfected with: UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Disease Hepatocellular carcinoma of the mouse (NCIt: C38756)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57L.
Hierarchy Parent: CVCL_0328 (Hepa-1c1c7)
Sex of cell Female
Category Cancer cell line
Publications

PubMed=18835618; DOI=10.1016/j.chemosphere.2008.08.015
Takeuchi S., Iida M., Yabushita H., Matsuda T., Kojima H.
In vitro screening for aryl hydrocarbon receptor agonistic activity in 200 pesticides using a highly sensitive reporter cell line, DR-EcoScreen cells, and in vivo mouse liver cytochrome P450-1A induction by propanil, diuron and linuron.
Chemosphere 74:155-165(2008)

PubMed=26087926; DOI=10.1007/s11356-015-4662-9
Kojima H., Takeuchi S., Iida M., Nakayama S.F., Shiozaki T.
A sensitive, rapid, and simple DR-EcoScreen bioassay for the determination of PCDD/Fs and dioxin-like PCBs in environmental and food samples.
Environ. Sci. Pollut. Res. 25:7101-7112(2018)

Cross-references
Cell line collections (Providers) JCRB; JCRB1630
Encyclopedic resources Wikidata; Q54831397
Entry history
Entry creation13-Jul-2016
Last entry update05-Oct-2023
Version number12