ID   DR-EcoScreen
AC   CVCL_EG66
DR   JCRB; JCRB1630
DR   Wikidata; Q54831397
RX   PubMed=18835618;
RX   PubMed=26087926;
CC   Biotechnology: Used in a bioassay for the determination of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (DL-PCBs) in environmental and food samples.
CC   Characteristics: Acts through the activation of a luciferase reporter gene under the control of dioxin-response elements (DREs).
CC   Transfected with: UniProtKB; P08659; Firefly luciferase.
CC   Transfected with: UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
CC   Breed/subspecies: C57L.
DI   NCIt; C38756; Hepatocellular carcinoma of the mouse
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_0328 ! Hepa-1c1c7
SX   Female
CA   Cancer cell line
DT   Created: 13-07-16; Last updated: 05-10-23; Version: 12
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RX   PubMed=18835618; DOI=10.1016/j.chemosphere.2008.08.015;
RA   Takeuchi S., Iida M., Yabushita H., Matsuda T., Kojima H.;
RT   "In vitro screening for aryl hydrocarbon receptor agonistic activity
RT   in 200 pesticides using a highly sensitive reporter cell line,
RT   DR-EcoScreen cells, and in vivo mouse liver cytochrome P450-1A
RT   induction by propanil, diuron and linuron.";
RL   Chemosphere 74:155-165(2008).
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RX   PubMed=26087926; DOI=10.1007/s11356-015-4662-9;
RA   Kojima H., Takeuchi S., Iida M., Nakayama S.F., Shiozaki T.;
RT   "A sensitive, rapid, and simple DR-EcoScreen bioassay for the
RT   determination of PCDD/Fs and dioxin-like PCBs in environmental and
RT   food samples.";
RL   Environ. Sci. Pollut. Res. 25:7101-7112(2018).
//