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Cellosaurus MBU-Ts4 (CVCL_EG15)

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Cell line name MBU-Ts4
Synonyms MBU-TS4; Ts4
Accession CVCL_EG15
Resource Identification Initiative To cite this cell line use: MBU-Ts4 (RRID:CVCL_EG15)
Comments Characteristics: Derived from a xenograft produced by injection of the parent cell line in nude mice.
Doubling time: ~80-100 hours (DSMZ=ACC-801).
Karyotypic information: 47,XY,+20 [5]; 46,XY,-13,+20 [3]; 47,XY,-13,+20,+mar [3] (PubMed=27074337).
Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Foreskin, skin, epidermis; UBERON=UBERON_0001471+UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_EG13 (MBU-T)
Sex of cell Male
Age at sampling <1D
Category Transformed cell line
STR profile Source(s): DSMZ=ACC-801

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133824
D3S135816,17
D5S81810,12
D7S8208,11
D8S117912,13
D13S3178,11
D16S53911,12
D18S5113,15
D19S43313,14
D21S1129,33.2
FGA20,22
Penta D9,14
Penta E10,14
TH018,9.3
TPOX8
vWA13,15

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Publications

PubMed=27074337; DOI=10.1002/ijc.30139
Neus Cantarino, Maite Teresa Fernandez-Figueras, Vanesa Valero, Eva Musulen, Roberto Malinverni, Isabel Granada, Stephen J. Goldie, Juan Martin-Caballero, Julien Douet, Sonia-Vanina Forcales, Marcus Buschbeck;
A cellular model reflecting the phenotypic heterogeneity of mutant HRAS driven squamous cell carcinoma.
Int. J. Cancer 139:1106-1116(2016)

Cross-references
Cell line collections (Providers) DSMZ; ACC-801
Cell line databases/resources DSMZCellDive; ACC-801
Encyclopedic resources Wikidata; Q54904162
Gene expression databases GEO; GSM1687269
GEO; GSM1687270
GEO; GSM1687271
Entry history
Entry creation13-Jul-2016
Last entry update14-Aug-2025
Version number15