| Cell line name |
CHO/159-1 |
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| Accession |
CVCL_E7EP |
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| Resource Identification Initiative |
To cite this cell line use: CHO/159-1 (RRID:CVCL_E7EP) |
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| Comments |
Selected for resistance to: ChEBI; CHEBI_50225; Razoxane (ICRF-159).
Transformant: NCIt; C17231; Ultraviolet radiation.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064. |
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| Sequence variations |
- Mutation; UniProtKB; P41515; Top2a; Simple; p.Tyr49Phe (c.146A>T); Zygosity=Heterozygous (PubMed=9537249).
- Mutation; UniProtKB; P41515; Top2a; Simple; p.Gln308_Ser312del (c.922_936del); Zygosity=Heterozygous (PubMed=9537249).
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| Species of origin |
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
(NCBI Taxonomy: 10029) |
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| Hierarchy |
Parent: CVCL_0213 (CHO) |
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| Sex of cell |
Female |
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| Age at sampling |
Adult |
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| Category |
Transformed cell line |
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| Publications | CLPUB00790
Kenwrick S.J., Creighton A.M.
Isolation and characterization of a subline of CHO cells with induced resistance to ICRF 159.",
Br. J. Cancer 46:504-505(1982) CLPUB00791
Kenwrick S.J.
Studies on the mechanism of induced resistance to antitumour agent ICRF 159 in mammalian cell lines.
Thesis PhD (1985); University of London; London; United Kingdom PubMed=9537249
Sehested M., Wessel I., Jensen L.H., Holm B., Oliveri R.S., Kenwrick S.J., Creighton A.M., Nitiss J.L., Jensen P.B.
Chinese hamster ovary cells resistant to the topoisomerase II catalytic inhibitor ICRF-159: a Tyr49Phe mutation confers high-level resistance to bisdioxopiperazines.
Cancer Res. 58:1460-1468(1998) |
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| Entry history |
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| Entry creation | 10-Apr-2025 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 1 |
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