| Cell line name |
CHO/159-1 |
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| Accession |
CVCL_E7EP |
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| Resource Identification Initiative |
To cite this cell line use: CHO/159-1 (RRID:CVCL_E7EP) |
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| Comments |
Selected for resistance to: ChEBI; CHEBI_50225; Razoxane (ICRF-159).
Transformant: NCIt; C17231; Ultraviolet radiation.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064. |
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| Sequence variations |
- Mutation; UniProtKB; P41515; Top2a; Simple; p.Tyr49Phe (c.146A>T); Zygosity=Heterozygous (PubMed=9537249).
- Mutation; UniProtKB; P41515; Top2a; Simple; p.Gln308_Ser312del (c.922_936del); Zygosity=Heterozygous (PubMed=9537249).
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| Species of origin |
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
(NCBI Taxonomy: 10029) |
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| Hierarchy |
Parent: CVCL_0213 (CHO) |
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| Sex of cell |
Female |
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| Age at sampling |
Adult |
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| Category |
Transformed cell line |
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| Publications | CLPUB00790
Susan Jane Kenwrick, Andrew M. Creighton;
Isolation and characterization of a subline of CHO cells with induced resistance to ICRF 159.
Br. J. Cancer 46:504-505(1982) CLPUB00791
Susan Jane Kenwrick;
Studies on the mechanism of induced resistance to antitumour agent ICRF 159 in mammalian cell lines.
Thesis PhD (1985); University of London; London; United Kingdom PubMed=9537249
Maxwell Sehested, Irene Wessel, Lars H. Jensen, Bente Holm, Roberto S. Oliveri, Susan Jane Kenwrick, Andrew M. Creighton, John L. Nitiss, Peter Buhl Jensen;
Chinese hamster ovary cells resistant to the topoisomerase II catalytic inhibitor ICRF-159: a Tyr49Phe mutation confers high-level resistance to bisdioxopiperazines.
Cancer Res. 58:1460-1468(1998) |
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| Entry history |
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| Entry creation | 10-Apr-2025 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 1 |
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