ID   CHO/159-1
AC   CVCL_E7EP
RX   CelloPub=CLPUB00790;
RX   CelloPub=CLPUB00791;
RX   PubMed=9537249;
CC   Selected for resistance to: ChEBI; CHEBI_50225; Razoxane (ICRF-159).
CC   Sequence variation: Mutation; UniProtKB; P41515; Top2a; Simple; p.Tyr49Phe (c.146A>T); Zygosity=Heterozygous (PubMed=9537249).
CC   Sequence variation: Mutation; UniProtKB; P41515; Top2a; Simple; p.Gln308_Ser312del (c.922_936del); Zygosity=Heterozygous (PubMed=9537249).
CC   Transformant: NCIt; C17231; Ultraviolet radiation.
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_0213 ! CHO
SX   Female
AG   Adult
CA   Transformed cell line
DT   Created: 10-04-25; Last updated: 10-04-25; Version: 1
//
RX   CelloPub=CLPUB00790;
RA   Kenwrick S.J., Creighton A.M.;
RT   "Isolation and characterization of a subline of CHO cells with induced
RT   resistance to ICRF 159.",
RL   Br. J. Cancer 46:504-505(1982).
//
RX   CelloPub=CLPUB00791;
RA   Kenwrick S.J.;
RT   "Studies on the mechanism of induced resistance to antitumour agent
RT   ICRF 159 in mammalian cell lines.";
RL   Thesis PhD (1985); University of London; London; United Kingdom.
//
RX   PubMed=9537249;
RA   Sehested M., Wessel I., Jensen L.H., Holm B., Oliveri R.S., Kenwrick S.J.,
RA   Creighton A.M., Nitiss J.L., Jensen P.B.;
RT   "Chinese hamster ovary cells resistant to the topoisomerase II
RT   catalytic inhibitor ICRF-159: a Tyr49Phe mutation confers high-level
RT   resistance to bisdioxopiperazines.";
RL   Cancer Res. 58:1460-1468(1998).
//