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Cellosaurus Ba/F3 FLT3-ITD [Malmo] (CVCL_E6Y7)

[Text version]
Cell line name Ba/F3 FLT3-ITD [Malmo]
Accession CVCL_E6Y7
Resource Identification Initiative To cite this cell line use: Ba/F3 FLT3-ITD [Malmo] (RRID:CVCL_E6Y7)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:3765; FLT3 (Note=With ITD).
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Caution: The parent cell line was originally thought to originate from a BALB/c mouse but is in fact from a C3H mouse.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: Pro-B cell; CL=CL_0000826.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C3H.
Hierarchy Parent: CVCL_0161 (Ba/F3)
Category Factor-dependent cell line
Publications

PubMed=19438505; DOI=10.1111/j.1365-2141.2009.07725.x
Kristina Masson, Tao Liu, Rasheed Khan, Jian-Min Sun, Lars Ronnstrand;
A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival.
Br. J. Haematol. 146:193-202(2009)

PubMed=28271164; DOI=10.1007/s00018-017-2494-0; PMCID=PMC5487891
Julhash Uddin Kazi, Rohit Annasaheb Chougule, Tian-Feng Li, Xian-Wei Su, Sausan A. Moharram, Kaja Rupar, Alissa Marhall, Mohiuddin Gazi, Jian-Min Sun, Hui Zhao, Lars Ronnstrand;
Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD.
Cell. Mol. Life Sci. 74:2679-2688(2017)

Entry history
Entry creation10-Apr-2025
Last entry update14-Aug-2025
Version number2