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Cellosaurus NCI-H1975 EGFR-D770_N771insSVD_Luc (CVCL_E6DE)

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Cell line name NCI-H1975 EGFR-D770_N771insSVD_Luc
Synonyms NCI-H1975 EGFR D770_N771insSVD_Luc
Accession CVCL_E6DE
Resource Identification Initiative To cite this cell line use: NCI-H1975 EGFR-D770_N771insSVD_Luc (RRID:CVCL_E6DE)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:3236; EGFR (Note=With p.Asp770_Asn771insSerValAsp (c.2311_2312insGCGTGGACA)).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transfection; Gene=UniProtKB; P08659; Firefly luciferase.
Genetic integration: Method=Transfection; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple_corrected; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Heterozygous; Note=By TALEN (PubMed=29748209).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple_corrected; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous; Note=By TALEN (PubMed=29748209).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gly118Asp (c.353G>A); ClinVar=VCV000156446; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_E6DD (NCI-H1975 EGFR-D770_N771insSVD)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=29748209; DOI=10.1158/1535-7163.MCT-17-1206
Hasako S., Terasaka M., Abe N., Uno T., Ohsawa H., Hashimoto A., Fujita R., Tanaka K., Okayama T., Wadhwa R., Miyadera K., Aoyagi Y., Yonekura K., Matsuo K.
TAS6417, a novel EGFR inhibitor targeting exon 20 insertion mutations.
Mol. Cancer Ther. 17:1648-1658(2018)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1