Cellosaurus cell line NCI-H1975 EGFR-D770_N771insSVD (CVCL

Cellosaurus NCI-H1975 EGFR-D770_N771insSVD (CVCL_E6DD)

[Text version]

Cell line name

NCI-H1975 EGFR-D770_N771insSVD

Synonyms

NCI-H1975 EGFR D770_N771insSVD; H1975-insSVD

Accession

CVCL_E6DD

Resource Identification Initiative

To cite this cell line use: NCI-H1975 EGFR-D770_N771insSVD (RRID:CVCL_E6DD)

Comments

Population: Caucasian.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:3236; EGFR (Note=With p.Asp770_Asn771insSerValAsp (c.2311_2312insGCGTGGACA)).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.

Sequence variations

Mutation; HGNC; HGNC:3236; EGFR; Simple_corrected; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Heterozygous; Note=By TALEN (PubMed=29748209).
Mutation; HGNC; HGNC:3236; EGFR; Simple_corrected; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous; Note=By TALEN (PubMed=29748209).
Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gly118Asp (c.353G>A); ClinVar=VCV000156446; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).

Disease

Lung adenocarcinoma (NCIt: C3512)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_1511 (NCI-H1975)
Children:

CVCL_E6DE (NCI-H1975 EGFR-D770_N771insSVD_Luc)

Sex of cell

Female

Age at sampling

Age unspecified