ID   NCI-H1975 EGFR-D770_N771insSVD_Luc
AC   CVCL_E6DE
SY   NCI-H1975 EGFR D770_N771insSVD_Luc
RX   PubMed=29748209;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple_corrected; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Heterozygous; Note=By TALEN (PubMed=29748209).
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple_corrected; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous; Note=By TALEN (PubMed=29748209).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gly118Asp (c.353G>A); ClinVar=VCV000156446; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:3236; EGFR (Note=With p.Asp770_Asn771insSerValAsp (c.2311_2312insGCGTGGACA)).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P08659; Firefly luciferase.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_E6DD ! NCI-H1975 EGFR-D770_N771insSVD
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 10-04-25; Last updated: 10-04-25; Version: 1
//
RX   PubMed=29748209; DOI=10.1158/1535-7163.MCT-17-1206;
RA   Hasako S., Terasaka M., Abe N., Uno T., Ohsawa H., Hashimoto A.,
RA   Fujita R., Tanaka K., Okayama T., Wadhwa R., Miyadera K., Aoyagi Y.,
RA   Yonekura K., Matsuo K.;
RT   "TAS6417, a novel EGFR inhibitor targeting exon 20 insertion
RT   mutations.";
RL   Mol. Cancer Ther. 17:1648-1658(2018).
//