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Cellosaurus CAL-51 RRAS2 KO#11 (CVCL_E5L3)

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Cell line name CAL-51 RRAS2 KO#11
Accession CVCL_E5L3
Resource Identification Initiative To cite this cell line use: CAL-51 RRAS2 KO#11 (RRID:CVCL_E5L3)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:17271; RRAS2.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Heterozygous (from parent cell line).
Disease Breast carcinoma (NCIt: C4872)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1110 (CAL-51)
Sex of cell Female
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=36476833; DOI=10.1038/s41388-022-02563-9; PMCID=PMC9883167
Laura Clavain, Maria Isabel Fernandez-Pisonero, Nieves Movilla, Luis Francisco Lorenzo-Martin, Blanca Nieto, Antonio Abad, Rosula Garcia-Navas, Clara Llorente-Gonzalez, Manuel Sanchez-Martin, Miguel Vicente-Manzanares, Eugenio Santos ...Show all 15 authors... , Balbino Alarcon, Jose Manuel Garcia-Aznar, Mercedes Dosil, Xose R. Bustelo; Show fewer authors
Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors.
Oncogene 42:389-405(2023)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1