ID   CAL-51 RRAS2 KO#11
AC   CVCL_E5L3
RX   PubMed=36476833;
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Population: Caucasian.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:17271; RRAS2.
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4872; Breast carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1110 ! CAL-51
SX   Female
AG   45Y
CA   Cancer cell line
DT   Created: 10-04-25; Last updated: 10-04-25; Version: 1
//
RX   PubMed=36476833; DOI=10.1038/s41388-022-02563-9; PMCID=PMC9883167;
RA   Clavain L., Fernandez-Pisonero M.I., Movilla N., Lorenzo-Martin L.F.,
RA   Nieto B., Abad A., Garcia-Navas R., Llorente-Gonzalez C.,
RA   Sanchez-Martin M., Vicente-Manzanares M., Santos E., Alarcon B.,
RA   Garcia-Aznar J.M., Dosil M., Bustelo X.R.;
RT   "Characterization of mutant versions of the R-RAS2/TC21 GTPase found
RT   in tumors.";
RL   Oncogene 42:389-405(2023).
//