Cellosaurus logo
expasy logo

Cellosaurus NHA E6/E7/hTERT/Ras (CVCL_E3G4)

[Text version]
Cell line name NHA E6/E7/hTERT/Ras
Accession CVCL_E3G4
Resource Identification Initiative To cite this cell line use: NHA E6/E7/hTERT/Ras (RRID:CVCL_E3G4)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Cell type: Astrocyte; CL=CL_0000127.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_E3G5 (NHA E6/E7/hTERT/Ras/Akt)CVCL_Z595 (SK-astrocyte-IDH1)CVCL_Z596 (SK-astrocyte-IDH1-R132H)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Transformed cell line
Publications

PubMed=11431323
Yukihiko Sonoda, Tomoko Ozawa, Yuichi Hirose, Kenneth D. Aldape, Martin McMahon, Mitchel Stuart Berger, Russell O. Pieper;
Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma.
Cancer Res. 61:4956-4960(2001)

PubMed=11559533
Yukihiko Sonoda, Tomoko Ozawa, Kenneth D. Aldape, Dennis F. Deen, Mitchel Stuart Berger, Russell O. Pieper;
Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma.
Cancer Res. 61:6674-6678(2001)

Entry history
Entry creation19-Dec-2024
Last entry update14-Aug-2025
Version number2