ID   NHA E6/E7/hTERT/Ras
AC   CVCL_E3G4
RX   PubMed=11431323;
RX   PubMed=11559533;
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
CC   Cell type: Astrocyte; CL=CL_0000127.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Transformed cell line
DT   Created: 19-12-24; Last updated: 19-12-24; Version: 1
//
RX   PubMed=11431323;
RA   Sonoda Y., Ozawa T., Hirose Y., Aldape K.D., McMahon M., Berger M.S.,
RA   Pieper R.O.;
RT   "Formation of intracranial tumors by genetically modified human
RT   astrocytes defines four pathways critical in the development of human
RT   anaplastic astrocytoma.";
RL   Cancer Res. 61:4956-4960(2001).
//
RX   PubMed=11559533;
RA   Sonoda Y., Ozawa T., Aldape K.D., Deen D.F., Berger M.S., Pieper R.O.;
RT   "Akt pathway activation converts anaplastic astrocytoma to
RT   glioblastoma multiforme in a human astrocyte model of glioma.";
RL   Cancer Res. 61:6674-6678(2001).
//