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Cellosaurus FT246-YAP(S127A) (CVCL_E3FH)

[Text version]
Cell line name FT246-YAP(S127A)
Synonyms FT246-YAPS127A
Accession CVCL_E3FH
Resource Identification Initiative To cite this cell line use: FT246-YAP(S127A) (RRID:CVCL_E3FH)
Comments Knockout cell: Method=shRNA knockdown; HGNC; HGNC:11998; TP53.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1773; CDK4 (Note=With p.Arg24Cys).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:16262; YAP1 (Note=With p.Ser127Ala).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Fallopian tube; UBERON=UBERON_0003889.
Cell type: Fallopian tube secretory epithelial cell; CL=CL_4030006.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_UH61 (FT246)
Sex of cell Female
Age at sampling Age unspecified
Category Telomerase immortalized cell line
Publications

PubMed=26364602; DOI=10.1038/onc.2015.288; PMCID=PMC4791205
Hua G.-H., Lv X.-M., He C.-B., Remmenga S.W., Rodabaugh K.J., Dong J.-X., Yang L., Lele S.M., Yang P., Zhou J., Karst A.M., Drapkin R.I., Davis J.S., Wang C.
YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells.
Oncogene 35:2247-2265(2016)

Entry history
Entry creation19-Dec-2024
Last entry update19-Dec-2024
Version number1