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Cellosaurus FT246 (CVCL_UH61)

[Text version]
Cell line name FT246
Synonyms iFTSEC246; hTERT FT 246
Accession CVCL_UH61
Resource Identification Initiative To cite this cell line use: FT246 (RRID:CVCL_UH61)
Comments Doubling time: ~32 hours (ATCC=CRL-3448).
Knockout cell: Method=shRNA knockdown; HGNC; HGNC:11998; TP53.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1773; CDK4 (Note=With p.Arg24Cys).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Omics: Genomics; ChIP-seq; H3K27ac.
Omics: Genomics; ChIP-seq; H3K4me1.
Derived from site: In situ; Fallopian tube; UBERON=UBERON_0003889.
Cell type: Fallopian tube secretory epithelial cell; CL=CL_4030006.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_E3FI (FT246-MXIV)CVCL_E3FG (FT246-YAP)CVCL_E3FH (FT246-YAP(S127A))
Sex of cell Female
Age at sampling Age unspecified
Category Telomerase immortalized cell line
STR profile Source(s): ATCC=CRL-3448

Markers:
AmelogeninX
CSF1PO10,12
D5S81811,12
D7S82011
D13S3179,10
D16S5399,13
TH018,9.3
TPOX8,11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=22936217; DOI=10.1038/nprot.2012.097; PMCID=PMC7433321
Alison M. Karst, Ronny I. Drapkin;
Primary culture and immortalization of human fallopian tube secretory epithelial cells.
Nat. Protoc. 7:1755-1764(2012)

PubMed=25804953; DOI=10.1093/hmg/ddv101; PMCID=PMC4459387
Simon Gert Coetzee, Howard C. Shen, Dennis J. Hazelett, Kate Lawrenson, Karoline Kuchenbaecker, Jonathan P. Tyrer, Suhn K. Rhie, Keren Levanon, Alison M. Karst, Ronny I. Drapkin, Susan J. Ramus ...Show all 21 authors... , Fergus J. Couch, Kenneth Offit, Georgia Chenevix-Trench, Alvaro N.A. Monteiro, Antonis Antoniou, Matthew Lawrence Freedman, Gerhard A. Coetzee, Paul D.P. Pharoah, Houtan Noushmehr, Simon Andrew Gayther; Show fewer authors
Consortium of Investigators of Modifiers of BRCA1/2
Ovarian Cancer Association Consortium
Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci.
Hum. Mol. Genet. 24:3595-3607(2015)

PubMed=26364602; DOI=10.1038/onc.2015.288; PMCID=PMC4791205
Guo-Hua Hua, Xiang-Min Lv, Chun-Bo He, Steven Wesley Remmenga, Kerry Julene Rodabaugh, Ji-Xin Dong, Li-Guo Yang, Subodh Mukund Lele, Pei-Xin Yang, Jin Zhou, Alison M. Karst ...Show all 14 authors... , Ronny I. Drapkin, John S. Davis, Cheng Wang; Show fewer authors
YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells.
Oncogene 35:2247-2265(2016)

PubMed=30487138; DOI=10.1158/0008-5472.CAN-17-3864; PMCID=PMC6359979
Melissa A. Buckley, Nicholas T. Woods, Jonathan P. Tyrer, Gustavo Mendoza-Fandino, Kate Lawrenson, Dennis J. Hazelett, Hamed S. Najafabadi, Anxhela Gjyshi, Renato S. Carvalho, Paulo C. Lyra Jr., Simon Gert Coetzee ...Show all 27 authors... , Howard C. Shen, Ally W. Yang, Madalene A. Earp, Sean J. Yoder, Harvey Risch, Georgia Chenevix-Trench, Susan J. Ramus, Catherine M. Phelan, Gerhard A. Coetzee, Houtan Noushmehr, Timothy R. Hughes, Thomas A. Sellers, Ellen L. Goode, Paul D.P. Pharoah, Simon Andrew Gayther, Alvaro N.A. Monteiro; Show fewer authors
Functional analysis and fine mapping of the 9p22.2 ovarian cancer susceptibility locus.
Cancer Res. 79:467-481(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-3448
Encyclopedic resources Wikidata; Q93557163
Gene expression databases GEO; GSM1663016
GEO; GSM1663017
GEO; GSM1663018
GEO; GSM1663019
GEO; GSM1663020
GEO; GSM1663021
GEO; GSM1663022
GEO; GSM1663023
Entry history
Entry creation25-Feb-2019
Last entry update14-Aug-2025
Version number12