Cellosaurus logo
expasy logo

Cellosaurus NLF (CVCL_E217)

[Text version]
Cell line name NLF
Synonyms NLF-Trk-NULL
Accession CVCL_E217
Resource Identification Initiative To cite this cell line use: NLF (RRID:CVCL_E217)
Comments Omics: Array-based CGH.
Omics: N-glycan profiling.
Omics: SNP array analysis.
Omics: Transcriptome analysis by RNAseq.
Sequence variations
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Arg524Met (c.1571G>T); Zygosity=Heterozygous (PubMed=16822308).
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_UJ92 (NLF-TrkA, clone #2)CVCL_UJ93 (NLF-TrkB, clone #6)CVCL_RR42 (NLFrCARBO5000)
CVCL_RR43 (NLFrCDDP1000)CVCL_RS77 (NLFrCDDP500)CVCL_RR44 (NLFrDACARB20)
CVCL_RR45 (NLFrDOCE20)CVCL_RR46 (NLFrDOX40)CVCL_RR47 (NLFrETO100)
CVCL_RR48 (NLFrGEMCI20)CVCL_RS78 (NLFrIRINO1000)CVCL_RR49 (NLFrMEL3000)
CVCL_RR50 (NLFrOXALI4000)CVCL_RR76 (NLFrPCL20)CVCL_RR74 (NLFrTOPO10)
CVCL_RR51 (NLFrVCR10)CVCL_RR52 (NLFrVCR5)CVCL_RR77 (NLFrVINB10)
CVCL_RS79 (NLFrVINOR10)
Sex of cell Male
Age at sampling 3Y
Category Cancer cell line
Publications

PubMed=6888561; DOI=10.1038/305245a0
Schwab M., Alitalo K., Klempnauer K.-H., Varmus H.E., Bishop J.M., Gilbert F., Brodeur G.M., Goldstein M.N., Trent J.M.
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour.
Nature 305:245-248(1983)

DOI=10.1016/B978-0-12-333530-2.50006-X
Israel M.A., Thiele C.J.
Tumor cell lines of the peripheral nervous system.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York; USA (1994)

DOI=10.1007/0-306-46872-7_2
Thiele C.J.
Neuroblastoma.
(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999)

PubMed=11550280; DOI=10.1002/gcc.1174
Van Roy N., Van Limbergen H., Vandesompele J., Van Gele M., Poppe B., Salwen H.R., Laureys G., Manoel N., De Paepe A., Speleman F.
Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines.
Genes Chromosomes Cancer 32:126-135(2001)

PubMed=15892104; DOI=10.1002/gcc.20198
Mosse Y.P., Greshock J., Margolin A.A., Naylor T., Cole K.A., Khazi D., Hii G., Winter C., Shahzad S., Asziz M.U., Biegel J.A., Weber B.L., Maris J.M.
High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.
Genes Chromosomes Cancer 43:390-403(2005)

PubMed=16822308; DOI=10.1186/1471-2407-6-177; PMCID=PMC1533846
Dam V., Morgan B.T., Mazanek P., Hogarty M.D.
Mutations in PIK3CA are infrequent in neuroblastoma.
BMC Cancer 6:177.1-177.10(2006)

PubMed=18724359; DOI=10.1038/nature07261; PMCID=PMC2672043
Mosse Y.P., Laudenslager M., Longo L., Cole K.A., Wood A., Attiyeh E.F., Laquaglia M.J., Sennett R., Lynch J.E., Perri P., Laureys G., Speleman F., Kim C., Hou C.-P., Hakonarson H., Torkamani A., Schork N.J., Brodeur G.M., Tonini G.P., Rappaport E., Devoto M., Maris J.M.
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 455:930-935(2008)

PubMed=23202128; DOI=10.1038/ng.2493; PMCID=PMC3557959
Sausen M., Leary R.J., Jones S., Wu J., Reynolds C.P., Liu X.-Y., Blackford A.L., Parmigiani G., Diaz L.A. Jr., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E., Hogarty M.D.
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Nat. Genet. 45:12-17(2013)

PubMed=24466371; DOI=10.1593/tlo.13544; PMCID=PMC3890703
Loschmann N., Michaelis M., Rothweiler F., Zehner R., Cinatl J., Voges Y., Sharifi M., Riecken K., Meyer J., von Deimling A., Fichtner I., Ghafourian T., Westermann F., Cinatl J. Jr.
Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.
Transl. Oncol. 6:685-696(2013)

PubMed=25730103; DOI=10.1021/pr5011718; PMCID=PMC4516140
Hu Y.-L., Mayampurath A., Khan S., Cohen J.K., Mechref Y., Volchenboum S.L.
N-linked glycan profiling in neuroblastoma cell lines.
J. Proteome Res. 14:2074-2081(2015)

PubMed=28350380; DOI=10.1038/sdata.2017.33; PMCID=PMC5369315
Harenza J.L., Diamond M.A., Adams R.N., Song M.M., Davidson H.L., Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033-170033(2017)

Cross-references
Cell line collections (Providers) Kerafast; ECP008
Encyclopedic resources Wikidata; Q54930689
Gene expression databases GEO; GSM2371250
GEO; GSM2394370
GEO; GSM3145727
Polymorphism and mutation databases Cosmic; 697276
Cosmic; 717423
Cosmic; 848928
Cosmic; 923824
Cosmic; 930072
Cosmic; 1019953
Cosmic; 1162000
Cosmic; 1526638
Cosmic; 2393639
Entry history
Entry creation22-Oct-2012
Last entry update21-Mar-2023
Version number21