Cellosaurus logo
expasy logo

Cellosaurus NLF (CVCL_E217)

[Text version]
Cell line name NLF
Synonyms NLF-Trk-NULL
Accession CVCL_E217
Resource Identification Initiative To cite this cell line use: NLF (RRID:CVCL_E217)
Comments Omics: Glycomics; N-glycan profiling.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Sequence variations
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Arg524Met (c.1571G>T); Zygosity=Heterozygous (PubMed=16822308).
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_UJ92 (NLF-TrkA, clone #2)CVCL_UJ93 (NLF-TrkB, clone #6)CVCL_RR42 (NLFrCARBO5000)
CVCL_RR43 (NLFrCDDP1000)CVCL_RS77 (NLFrCDDP500)CVCL_RR44 (NLFrDACARB20)
CVCL_RR45 (NLFrDOCE20)CVCL_RR46 (NLFrDOX40)CVCL_RR47 (NLFrETO100)
CVCL_RR48 (NLFrGEMCI20)CVCL_RS78 (NLFrIRINO1000)CVCL_RR49 (NLFrMEL3000)
CVCL_RR50 (NLFrOXALI4000)CVCL_RR76 (NLFrPCL20)CVCL_RR74 (NLFrTOPO10)
CVCL_RR51 (NLFrVCR10)CVCL_RR52 (NLFrVCR5)CVCL_RR77 (NLFrVINB10)
CVCL_RS79 (NLFrVINOR10)
Sex of cell Male
Age at sampling 3Y
Category Cancer cell line
Publications

PubMed=6888561; DOI=10.1038/305245a0
Manfred Schwab, Kari Alitalo, Karl-Heinz Klempnauer, Harold Eliot Varmus, John Michael Bishop, Fred Gilbert, Garrett M. Brodeur, Milton N. Goldstein, Jeffrey M. Trent;
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour.
Nature 305:245-248(1983)

DOI=10.1016/B978-0-12-333530-2.50006-X
Mark A. Israel, Carol Jeanne Thiele;
Tumor cell lines of the peripheral nervous system.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.43-78; Academic Press; New York; USA (1994)

DOI=10.1007/0-306-46872-7_2
Carol Jeanne Thiele;
Neuroblastoma.
(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999)

PubMed=11550280; DOI=10.1002/gcc.1174
Nadine Van Roy, Heidi Van Limbergen, Jo Vandesompele, Mireille Van Gele, Bruce Poppe, Helen R. Salwen, Genevieve Laureys, Nunes Manoel, Anne De Paepe, Frank Speleman;
Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines.
Genes Chromosomes Cancer 32:126-135(2001)

PubMed=15892104; DOI=10.1002/gcc.20198
Yael P. Mosse, Joel Greshock, Adam A. Margolin, Tara Naylor, Kristina A. Cole, Deepa Khazi, George Hii, Cynthia Winter, Syed Shahzad, Muhammad Usman Asziz, Jaclyn A. Biegel ...Show all 13 authors... , Barbara L. Weber, John Matthew Maris; Show fewer authors
High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.
Genes Chromosomes Cancer 43:390-403(2005)

PubMed=16822308; DOI=10.1186/1471-2407-6-177; PMCID=PMC1533846
Vincent Dam, Brian T. Morgan, Pavel Mazanek, Michael D. Hogarty;
Mutations in PIK3CA are infrequent in neuroblastoma.
BMC Cancer 6:177.1-177.10(2006)

PubMed=18724359; DOI=10.1038/nature07261; PMCID=PMC2672043
Yael P. Mosse, Marci Laudenslager, Luca Longo, Kristina A. Cole, Andrew Wood, Edward Fathi Attiyeh, Michael J. Laquaglia, Rachel Sennett, Jill E. Lynch, Patrizia Perri, Genevieve Laureys ...Show all 22 authors... , Frank Speleman, Cecilia Kim, Cui-Ping Hou, Hakon Hakonarson, Ali Torkamani, Nicholas J. Schork, Garrett M. Brodeur, Gian Paolo Tonini, Eric Rappaport, Marcella Devoto, John Matthew Maris; Show fewer authors
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 455:930-935(2008)

PubMed=23202128; DOI=10.1038/ng.2493; PMCID=PMC3557959
Mark Sausen, Rebecca J. Leary, Sian Jones, Jian Wu, Charles Patrick Reynolds, Xue-Yuan Liu, Amanda L. Blackford, Giovanni Parmigiani, Luis Alberto Diaz Jr., Nickolas Papadopoulos, Bert Vogelstein ...Show all 14 authors... , Kenneth Wayne Kinzler, Victor E. Velculescu, Michael D. Hogarty; Show fewer authors
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Nat. Genet. 45:12-17(2013)

PubMed=24466371; DOI=10.1593/tlo.13544; PMCID=PMC3890703
Nadine Loschmann, Martin Michaelis, Florian Rothweiler, Richard Zehner, Jaroslaw Cinatl, Yvonne Voges, Mohsen Sharifi, Kristoffer Riecken, Jochen Meyer, Andreas von Deimling, Iduna Fichtner ...Show all 14 authors... , Taravat Ghafourian, Frank Westermann, Jindrich Cinatl Jr.; Show fewer authors
Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.
Transl. Oncol. 6:685-696(2013)

PubMed=25730103; DOI=10.1021/pr5011718; PMCID=PMC4516140
Yun-Li Hu, Anoop Mayampurath, Saira Khan, Joanna K. Cohen, Yehia Mechref, Samuel Louis Volchenboum;
N-linked glycan profiling in neuroblastoma cell lines.
J. Proteome Res. 14:2074-2081(2015)

PubMed=28350380; DOI=10.1038/sdata.2017.33; PMCID=PMC5369315
Jo Lynne Harenza, Maura A. Diamond, Rebecca N. Adams, Michael M. Song, Heather L. Davidson, Lori S. Hart, Maiah H. Dent, Paolo Fortina, Charles Patrick Reynolds, John Matthew Maris;
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033.1-170033.8(2017)

Cross-references
Cell line collections (Providers) Kerafast; ECP008
Encyclopedic resources Wikidata; Q54930689
Gene expression databases GEO; GSM2371250
GEO; GSM2394370
GEO; GSM3145565
GEO; GSM3145727
Polymorphism and mutation databases Cosmic; 697276
Cosmic; 717423
Cosmic; 848928
Cosmic; 923824
Cosmic; 930072
Cosmic; 1019953
Cosmic; 1162000
Cosmic; 1526638
Cosmic; 2393639
Entry history
Entry creation22-Oct-2012
Last entry update14-Aug-2025
Version number24