Cellosaurus cell line IMA-KO-1 (CVCL

Cellosaurus IMA-KO-1 (CVCL_E1HW)

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Cell line name

IMA-KO-1

Accession

CVCL_E1HW

Resource Identification Initiative

To cite this cell line use: IMA-KO-1 (RRID:CVCL_E1HW)

Comments

Knockout cell: Method=Homologous recombination; HGNC; HGNC:5382; IDH1 (Note=1 of 2 alleles).
Derived from site: In situ; Brain; UBERON=UBERON_0000955.

Sequence variations

Mutation; HGNC; HGNC:886; ATRX; Simple; p.Arg781Ter (c.2341C>T); Zygosity=Unspecified (from parent cell line).
Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132His (c.395G>A); ClinVar=VCV000156444; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly245Val (c.734G>T); ClinVar=VCV000376603; Zygosity=Unspecified (from parent cell line).

Disease

Anaplastic astrocytoma (NCIt: C9477)
Anaplastic astrocytoma (ORDO: Orphanet_251589)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_E1HV (IMA)
Children:

CVCL_E1HY (IMA-KO-1-EV)

CVCL_E1HZ (IMA-KO-1-IDH1)

CVCL_E1I0 (IMA-KO-1-IDH1-R132H)

Sex of cell

Male

Age at sampling

26Y