Cellosaurus cell line IMA (CVCL

Cellosaurus IMA (CVCL_E1HV)

[Text version]

Cell line name

IMA

Synonyms

TB096; TB096-2; TB09-0096-2; IDH1-Mutated Astrocytoma

Accession

CVCL_E1HV

Resource Identification Initiative

To cite this cell line use: IMA (RRID:CVCL_E1HV)

Comments

Doubling time: ~72 hours (PubMed=23204232).
Derived from site: In situ; Brain; UBERON=UBERON_0000955.

Sequence variations

Mutation; HGNC; HGNC:886; ATRX; Simple; p.Arg781Ter (c.2341C>T); Zygosity=Unspecified (PubMed=23204232).
Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132His (c.395G>A); ClinVar=VCV000156444; Zygosity=Heterozygous (PubMed=23204232).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly245Val (c.734G>T); ClinVar=VCV000376603; Zygosity=Unspecified (PubMed=23204232).

Disease

Anaplastic astrocytoma (NCIt: C9477)
Anaplastic astrocytoma (ORDO: Orphanet_251589)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Children:

CVCL_E1HW (IMA-KO-1)

CVCL_E1HX (IMA-KO-2)

Sex of cell

Male

Age at sampling

26Y

Category

Cancer cell line

STR profile

Source(s): Millipore=SCC431

Markers:

Amelogenin	X,Y
CSF1PO	10,12
D3S1358	15
D5S818	13
D7S820	11,13
D8S1179	12,14
D13S317	8,14
D16S539	11
D18S51	16
D21S11	30
FGA	22,22.2
Penta D	14,15
Penta E	11,14
TH01	8,9.3
TPOX	11
vWA	15,17

Publications

PubMed=23204232; DOI=10.1158/0008-5472.CAN-12-2852; PMCID=PMC3548957
Geng-Lin Jin, Zachary James Reitman, Christopher G. Duncan, Ivan Spasojevic, David M. Gooden, B.K. Ahmed Rasheed, Rui Yang, Giselle Yvette Lopez, Yi-Ping He, Roger Edwin McLendon, Darell Doty Bigner, Hai Yan;
Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.
Cancer Res. 73:496-501(2013)

Cross-references

Cell line collections (Providers)

Millipore; SCC431

Entry history

Entry creation

10-Sep-2024

Last entry update

19-Dec-2024

Version number