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Cellosaurus IMA-KO-1-EV (CVCL_E1HY)

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Cell line name IMA-KO-1-EV
Accession CVCL_E1HY
Resource Identification Initiative To cite this cell line use: IMA-KO-1-EV (RRID:CVCL_E1HY)
Comments Characteristics: Control cell line for IMA-KO-1-IDH1 (Cellosaurus=CVCL_E1HZ) and IMA-KO-1-IDH1-R132H (Cellosaurus=CVCL_E1I0) (PubMed=23204232).
Knockout cell: Method=Homologous recombination; HGNC; HGNC:5382; IDH1 (Note=1 of 2 alleles).
Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; HGNC:886; ATRX; Simple; p.Arg781Ter (c.2341C>T); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132His (c.395G>A); ClinVar=VCV000156444; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly245Val (c.734G>T); ClinVar=VCV000376603; Zygosity=Unspecified (from parent cell line).
Disease Anaplastic astrocytoma (NCIt: C9477)
Anaplastic astrocytoma (ORDO: Orphanet_251589)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_E1HW (IMA-KO-1)
Sex of cell Male
Age at sampling 26Y
Category Cancer cell line
Publications

PubMed=23204232; DOI=10.1158/0008-5472.CAN-12-2852; PMCID=PMC3548957
Geng-Lin Jin, Zachary James Reitman, Christopher G. Duncan, Ivan Spasojevic, David M. Gooden, B.K. Ahmed Rasheed, Rui Yang, Giselle Yvette Lopez, Yi-Ping He, Roger Edwin McLendon, Darell Doty Bigner, Hai Yan;
Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.
Cancer Res. 73:496-501(2013)

Entry history
Entry creation10-Sep-2024
Last entry update14-Aug-2025
Version number3