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Cellosaurus HepHA-HBe4 (CVCL_DF33)

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Cell line name HepHA-HBe4
Accession CVCL_DF33
Resource Identification Initiative To cite this cell line use: HepHA-HBe4 (RRID:CVCL_DF33)
Comments Population: Caucasian.
Virology: Transfected with the HA-tagged HBeAg expression vector. This cell line can be used as a counter-screen to cell line HepBHAe82 (Cellosaurus=CVCL_DF32) (PubMed=27185623).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=27185623; DOI=10.1016/j.antiviral.2016.05.005; PMCID=PMC5060949
Da-Wei Cai, Xiao-He Wang, Ran Yan, Ri-Cheng Mao, Yuan-Jie Liu, Chang-Hua Ji, Andrea Cuconati, Hai-Tao Guo;
Establishment of an inducible HBV stable cell line that expresses cccDNA-dependent epitope-tagged HBeAg for screening of cccDNA modulators.
Antiviral Res. 132:26-37(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DF33
Encyclopedic resources Wikidata; Q54882868
Entry history
Entry creation13-Jul-2016
Last entry update27-Nov-2025
Version number16