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Cellosaurus HepBHAe82 (CVCL_DF32)

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Cell line name HepBHAe82
Synonyms HepBHAe-82
Accession CVCL_DF32
Resource Identification Initiative To cite this cell line use: HepBHAe82 (RRID:CVCL_DF32)
Comments Population: Caucasian.
Biotechnology: Used for a bioassay to detect HBV covalently closed circular (ccc) DNA.
Characteristics: Transfected with an in-frame influenza hemagglutinin (HA) epitope tag into the precore domain of hepatitis B virus (HBV) e antigen (HBeAg).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=27185623; DOI=10.1016/j.antiviral.2016.05.005; PMCID=PMC5060949
Da-Wei Cai, Xiao-He Wang, Ran Yan, Ri-Cheng Mao, Yuan-Jie Liu, Chang-Hua Ji, Andrea Cuconati, Hai-Tao Guo;
Establishment of an inducible HBV stable cell line that expresses cccDNA-dependent epitope-tagged HBeAg for screening of cccDNA modulators.
Antiviral Res. 132:26-37(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DF32
Encyclopedic resources Wikidata; Q54882837
Entry history
Entry creation13-Jul-2016
Last entry update19-Dec-2024
Version number17