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Cellosaurus BG1LucERbc9 (CVCL_DD13)

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Cell line name BG1LucERbc9
Synonyms BG1LucERbetac9
Accession CVCL_DD13
Resource Identification Initiative To cite this cell line use: BG1LucERbc9 (RRID:CVCL_DD13)
Comments Problematic cell line: Contaminated. Parent cell line (VM7Luc4E2) shown to be a MCF-7 derivative.
Population: Caucasian.
Characteristics: Developed to be used for identifying estrogen receptor agonists and antagonists.
Characteristics: Acts through the activation of a luciferase reporter gene under the control of estrogen response elements (EREs) upstream of the mouse mammary tumor viral (MMTV) promoter.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:3468; ESR2.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6571 (VM7Luc4E2)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

CLPUB00334
Jennifer C. Brennan;
Development; optimization, and application of nuclear receptor dependent cell-based bioassays for endocrine disruptors.
Thesis PhD (2015); University of California Davis; Davis; USA

PubMed=26139245; DOI=10.1002/etc.3146; PMCID=PMC4772679
Jennifer C. Brennan, Arzoo Bassal, Guo-Chun He, Michael S. Denison;
Development of a recombinant human ovarian (BG1) cell line containing estrogen receptor alpha and beta for improved detection of estrogenic/antiestrogenic chemicals.
Environ. Toxicol. Chem. 35:91-100(2016)

Cross-references
Encyclopedic resources Wikidata; Q54796234
Entry history
Entry creation13-Jul-2016
Last entry update14-Aug-2025
Version number13