ID   BG1LucERbc9
SY   BG1LucERbetac9
DR   Wikidata; Q54796234
RX   CelloPub=CLPUB00334;
RX   PubMed=26139245;
CC   Problematic cell line: Contaminated. Parent cell line (VM7Luc4E2) shown to be a MCF-7 derivative.
CC   Population: Caucasian.
CC   Characteristics: Developed to be used for identifying estrogen receptor agonists and antagonists.
CC   Characteristics: Acts through the activation of a luciferase reporter gene under the control of estrogen response elements (EREs) upstream of the mouse mammary tumor viral (MMTV) promoter.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: HGNC; 3468; ESR2.
CC   Transfected with: UniProtKB; P08659; Firefly luciferase.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6571 ! VM7Luc4E2
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 13-07-16; Last updated: 29-06-23; Version: 10
RX   CelloPub=CLPUB00334;
RA   Brennan J.C.;
RT   "Development, optimization, and application of nuclear receptor
RT   dependent cell-based bioassays for endocrine disruptors.";
RL   Thesis PhD (2015), University of California Davis, United States.
RX   PubMed=26139245; DOI=10.1002/etc.3146;
RA   Brennan J.C., Bassal A., He G.-C., Denison M.S.;
RT   "Development of a recombinant human ovarian (BG1) cell line containing
RT   estrogen receptor alpha and beta for improved detection of
RT   estrogenic/antiestrogenic chemicals.";
RL   Environ. Toxicol. Chem. 35:91-100(2016).