Cellosaurus logo
expasy logo

Cellosaurus SRD-3 (CVCL_DC36)

[Text][XML][JSON]
Cell line name SRD-3
Synonyms Sterol Regulatory Defective-3
Accession CVCL_DC36
Resource Identification Initiative To cite this cell line use: SRD-3 (RRID:CVCL_DC36)
Comments Transformant: ChEBI; CHEBI_23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Cell type: Fibroblast of lung; CL=CL_0002553.
Sequence variations
  • Mutation; UniProtKB; Q60429; Srebf2; Simple; p.Pro462_Ser1139del; Zygosity=Heterozygous (PubMed=7744865).
  • Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
  • Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_2234 (V79)
Sex of cell Male
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=1673968; DOI=10.1016/S0021-9258(18)31560-6
Paul A. Dawson, James E. Metherall, Neale David Ridgway, Michael Stuart Brown, Joseph Leonard Goldstein;
Genetic distinction between sterol-mediated transcriptional and posttranscriptional control of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
J. Biol. Chem. 266:9128-9134(1991)

PubMed=7744865; DOI=10.1074/jbc.270.20.12152
Jian-Xin Yang, Michael Stuart Brown, Y.K. Ho, Joseph Leonard Goldstein;
Three different rearrangements in a single intron truncate sterol regulatory element binding protein-2 and produce sterol-resistant phenotype in three cell lines. Role of introns in protein evolution.
J. Biol. Chem. 270:12152-12161(1995)

Cross-references
Encyclopedic resources Wikidata; Q54955661
Entry history
Entry creation13-Jul-2016
Last entry update19-Dec-2024
Version number13