ID   SRD-3
AC   CVCL_DC36
SY   Sterol Regulatory Defective-3
DR   Wikidata; Q54955661
RX   PubMed=1673968;
RX   PubMed=7744865;
CC   Sequence variation: Mutation; UniProtKB; Q60429; Srebf2; Simple; p.Pro462_Ser1139del; Zygosity=Heterozygous (PubMed=7744865).
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
CC   Transformant: ChEBI; CHEBI_23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
CC   Cell type: Fibroblast of lung; CL=CL_0002553.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_2234 ! V79
SX   Male
AG   Adult
CA   Transformed cell line
DT   Created: 13-07-16; Last updated: 19-12-24; Version: 13
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RX   PubMed=1673968; DOI=10.1016/S0021-9258(18)31560-6;
RA   Dawson, Paul A.
RA   Metherall, James E.
RA   Ridgway, Neale David
RA   Brown, Michael Stuart
RA   Goldstein, Joseph Leonard
RT   "Genetic distinction between sterol-mediated transcriptional and
RT   posttranscriptional control of 3-hydroxy-3-methylglutaryl-coenzyme A
RT   reductase.";
RL   J. Biol. Chem. 266:9128-9134(1991).
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RX   PubMed=7744865; DOI=10.1074/jbc.270.20.12152;
RA   Yang, Jian-Xin
RA   Brown, Michael Stuart
RA   Ho, Y.K.
RA   Goldstein, Joseph Leonard
RT   "Three different rearrangements in a single intron truncate sterol
RT   regulatory element binding protein-2 and produce sterol-resistant
RT   phenotype in three cell lines. Role of introns in protein evolution.";
RL   J. Biol. Chem. 270:12152-12161(1995).
//