Cellosaurus cell line H1L1.1c2 (CVCL

Cellosaurus H1L1.1c2 (CVCL_DC20)

Cross-references
Cell line name	H1L1.1c2
Synonyms	H1L1.1
Accession	CVCL_DC20
Resource Identification Initiative	To cite this cell line use: H1L1.1c2 (RRID:CVCL_DC20)
Comments	Group: Patented cell line. Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-12286. Biotechnology: Cell line developed for CALUX (Chemically Activated LUciferase eXpression) bioassay. CALUX is used for rapid screening of samples for the presence of dioxin/TCDD-like compounds and AhR agonists/antagonists. Characteristics: Acts through the activation of a luciferase reporter gene under the control of dioxin-response elements (DREs). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase. Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Disease	Hepatocellular carcinoma of the mouse (NCIt: C38756)
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: C57L/J.
Hierarchy	Parent: CVCL_0328 (Hepa-1c1c7)
Sex of cell	Female
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	PubMed=8812265; DOI=10.1006/faat.1996.0056 Patricia M. Garrison, Kathryn Tullis, Jac M.M.J.G. Aarts, Abraham Brouwer, John P. Giesy, Michael S. Denison; Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals. Fundam. Appl. Toxicol. 30:194-203(1996) Patent=US5854010 Michael S. Denison, Abraham Brouwer, George C. Clark; Bioassay for detecting 2,3,7,8-tetrachlorodibenzo-para-dioxin and TCDD-like compounds and novel recombinant cell line useful therefor. Patent number US5854010, 29-Dec-1998 PubMed=15096657; DOI=10.1002/biof.5520200102 Dalho Han, Scott R. Nagy, Michael S. Denison; Comparison of recombinant cell bioassays for the detection of Ah receptor agonists. BioFactors 20:11-22(2004) PubMed=18969542; DOI=10.1016/j.talanta.2004.05.032 Michael S. Denison, Bin Zhao, David S. Baston, George C. Clark, Hiroshi Murata, Dalho Han; Recombinant cell bioassay systems for the detection and relative quantitation of halogenated dioxins and related chemicals. Talanta 63:1123-1133(2004) PubMed=21394221; DOI=10.1007/s11426-010-0142-8; PMCID=PMC3049243 Bin Zhao, David S. Baston, Elaine Khan, Claudio Sorrentino, Michael S. Denison; Enhancing the response of CALUX and CAFLUX cell bioassays for quantitative detection of dioxin-like compounds. Sci. China Chem. 53:1010-1016(2010)
Encyclopedic resources	Wikidata; Q54871986
Entry history
Entry creation	13-Jul-2016
Last entry update	14-Aug-2025
Version number	13