ID   H1L1.1c2
AC   CVCL_DC20
SY   H1L1.1
DR   Wikidata; Q54871986
RX   Patent=US5854010;
RX   PubMed=8812265;
RX   PubMed=15096657;
RX   PubMed=18969542;
RX   PubMed=21394221;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-12286.
CC   Biotechnology: Cell line developed for CALUX (Chemically Activated LUciferase eXpression) bioassay. CALUX is used for rapid screening of samples for the presence of dioxin/TCDD-like compounds and AhR agonists/antagonists.
CC   Characteristics: Acts through the activation of a luciferase reporter gene under the control of dioxin-response elements (DREs).
CC   Transfected with: UniProtKB; P08659; Firefly luciferase.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
CC   Breed/subspecies: C57L.
DI   NCIt; C38756; Hepatocellular carcinoma of the mouse
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_0328 ! Hepa-1c1c7
SX   Female
CA   Cancer cell line
DT   Created: 13-07-16; Last updated: 29-06-23; Version: 10
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RX   Patent=US5854010;
RA   Denison M.S., Brouwer A., Clark G.C.;
RT   "Bioassay for detecting 2,3,7,8-tetrachlorodibenzo-para-dioxin and
RT   TCDD-like compounds and novel recombinant cell line useful therefor.";
RL   Patent number US5854010, 29-Dec-1998.
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RX   PubMed=8812265; DOI=10.1006/faat.1996.0056;
RA   Garrison P.M., Tullis K., Aarts J.M.M.J.G., Brouwer A., Giesy J.P.,
RA   Denison M.S.;
RT   "Species-specific recombinant cell lines as bioassay systems for the
RT   detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals.";
RL   Fundam. Appl. Toxicol. 30:194-203(1996).
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RX   PubMed=15096657; DOI=10.1002/biof.5520200102;
RA   Han D., Nagy S.R., Denison M.S.;
RT   "Comparison of recombinant cell bioassays for the detection of Ah
RT   receptor agonists.";
RL   BioFactors 20:11-22(2004).
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RX   PubMed=18969542; DOI=10.1016/j.talanta.2004.05.032;
RA   Denison M.S., Zhao B., Baston D.S., Clark G.C., Murata H., Han D.;
RT   "Recombinant cell bioassay systems for the detection and relative
RT   quantitation of halogenated dioxins and related chemicals.";
RL   Talanta 63:1123-1133(2004).
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RX   PubMed=21394221; DOI=10.1007/s11426-010-0142-8;
RA   Zhao B., Baston D.S., Khan E., Sorrentino C., Denison M.S.;
RT   "Enhancing the response of CALUX and CAFLUX cell bioassays for
RT   quantitative detection of dioxin-like compounds.";
RL   Sci. China Chem. 53:1010-1016(2010).
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