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Cellosaurus H1G1.1c3 (CVCL_DC19)

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Cell line name H1G1.1c3
Accession CVCL_DC19
Resource Identification Initiative To cite this cell line use: H1G1.1c3 (RRID:CVCL_DC19)
Comments Biotechnology: Cell line developed for CAFLUX (Chemically Activated FLUorescence eXpression) bioassay. CAFLUX is used for rapid screening of samples for the presence of dioxin/TCDD-like compounds and AhR agonists/antagonists.
Characteristics: Acts through the activation of a EGFP gene under the control of dioxin-response elements (DREs).
Genetic integration: Method=Transfection; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Disease Hepatocellular carcinoma of the mouse (NCIt: C38756)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57L/J.
Hierarchy Parent: CVCL_0328 (Hepa-1c1c7)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=11812924; DOI=10.1093/toxsci/65.2.200
Scott R. Nagy, James R. Sanborn, Bruce D. Hammock, Michael S. Denison;
Development of a green fluorescent protein-based cell bioassay for the rapid and inexpensive detection and characterization of ah receptor agonists.
Toxicol. Sci. 65:200-210(2002)

PubMed=15096657; DOI=10.1002/biof.5520200102
Dalho Han, Scott R. Nagy, Michael S. Denison;
Comparison of recombinant cell bioassays for the detection of Ah receptor agonists.
BioFactors 20:11-22(2004)

PubMed=21394221; DOI=10.1007/s11426-010-0142-8; PMCID=PMC3049243
Bin Zhao, David S. Baston, Elaine Khan, Claudio Sorrentino, Michael S. Denison;
Enhancing the response of CALUX and CAFLUX cell bioassays for quantitative detection of dioxin-like compounds.
Sci. China Chem. 53:1010-1016(2010)

Cross-references
Encyclopedic resources Wikidata; Q54871984
Entry history
Entry creation13-Jul-2016
Last entry update27-Nov-2025
Version number13