| Cell line name |
JJ012-TS4 |
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| Accession |
CVCL_D901 |
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| Resource Identification Initiative |
To cite this cell line use: JJ012-TS4 (RRID:CVCL_D901) |
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| Comments |
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:220; ADAMTS4. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132Gly (c.394C>G); ClinVar=VCV000375892; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly199Val (c.596G>T); ClinVar=VCV000451799; Zygosity=Unspecified (from parent cell line).
|
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| Disease |
Primary central chondrosarcoma (NCIt: C7155)
Chondrosarcoma (ORDO: Orphanet_55880) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_D605 (JJ012) |
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| Sex of cell |
Male |
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| Age at sampling |
39Y |
|---|
| Category |
Cancer cell line |
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| Publications | PubMed=11796708; DOI=10.1074/jbc.M107443200
Gui Gao, Jennifer Westling, Vivian P. Thompson, Troy D. Howell, Paul E. Gottschall, John David Sandy;
Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation.
J. Biol. Chem. 277:11034-11041(2002) PubMed=14701864; DOI=10.1074/jbc.M312100200
Gui Gao, Anna Plaas, Vivian P. Thompson, Sue Jin, Feng-Rong Zuo, John David Sandy;
ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1.
J. Biol. Chem. 279:10042-10051(2004) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_D901
|
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| Anatomy/cell type resources |
BTO; BTO_0003043
|
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| Encyclopedic resources |
Wikidata; Q54898951
|
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| Entry history |
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| Entry creation | 22-Oct-2012 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 19 |
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